Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs

Alteration in the pattern of epigenetic marking leads to cancer, neurological disorders, inflammatory problems etc. These changes are due to aberration in histone modification enzymes that function as readers, writers and erasers. Bromodomains (BDs) and BET proteins that recognize acetylation of chr...

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Detalles Bibliográficos
Autores principales: Muddassir, Mohd., Soni, Kunjal, Sangani, Chetan B., Alarifi, Abdullah, Afzal, Mohd., Abduh, Naaser A. Y., Duan, Yongtao, Bhadja, Poonam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133982/
https://www.ncbi.nlm.nih.gov/pubmed/35746919
http://dx.doi.org/10.1039/d0ra07971e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133982/
https://www.ncbi.nlm.nih.gov/pubmed/35746919
http://dx.doi.org/10.1039/d0ra07971e

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