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Monitoring haemodynamic changes in rodent models to better inform safety pharmacology: Novel insights from in vivo studies and waveform analysis
Animal models are essential for assessing cardiovascular responses to novel therapeutics. Cardiovascular safety liabilities represent a leading cause of drug attrition and better preclinical measurements are essential to predict drug-related toxicities. Presently, radiotelemetric approaches recordin...
Autores principales: | Van Daele, Marieke, Cooper, Samantha L, Pannucci, Patrizia, Wragg, Edward S, March, Julie, de Jong, Iwan, Woolard, Jeanette |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133998/ https://www.ncbi.nlm.nih.gov/pubmed/35646334 http://dx.doi.org/10.1177/20480040221092893 |
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