The UPR(mt) preserves mitochondrial import to extend lifespan

The mitochondrial unfolded protein response (UPR(mt)) is dedicated to promoting mitochondrial proteostasis and is linked to extreme longevity. The key regulator of this process is the transcription factor ATFS-1, which, upon UPR(mt) activation, is excluded from the mitochondria and enters the nucleu...

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Detalles Bibliográficos
Autores principales: Xin, Nan, Durieux, Jenni, Yang, Chunxia, Wolff, Suzanne, Kim, Hyun-Eui, Dillin, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134095/
https://www.ncbi.nlm.nih.gov/pubmed/35608535
http://dx.doi.org/10.1083/jcb.202201071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134095/
https://www.ncbi.nlm.nih.gov/pubmed/35608535
http://dx.doi.org/10.1083/jcb.202201071

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