Cargando…

The UPR(mt) preserves mitochondrial import to extend lifespan

The mitochondrial unfolded protein response (UPR(mt)) is dedicated to promoting mitochondrial proteostasis and is linked to extreme longevity. The key regulator of this process is the transcription factor ATFS-1, which, upon UPR(mt) activation, is excluded from the mitochondria and enters the nucleu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xin, Nan, Durieux, Jenni, Yang, Chunxia, Wolff, Suzanne, Kim, Hyun-Eui, Dillin, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134095/ https://www.ncbi.nlm.nih.gov/pubmed/35608535 http://dx.doi.org/10.1083/jcb.202201071

Ejemplares similares

Mitochondrial translational defect extends lifespan in C. elegans by activating UPR(mt)
por: Guo, Miaomiao, et al.
Publicado: (2023)

UPR(ER) promotes lipophagy independent of chaperones to extend life span
por: Daniele, Joseph R., et al.
Publicado: (2020)

Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR
por: Poveda-Huertes, Daniel, et al.
Publicado: (2021)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

UPR(mt) scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
por: Shpilka, Tomer, et al.
Publicado: (2021)

Temporal landscape of mitochondrial proteostasis governed by the UPR(mt)
por: Uoselis, Louise, et al.
Publicado: (2023)

UPR(mt) and coordinated UPR(ER) in type 2 diabetes
por: Kang, Zhanfang, et al.
Publicado: (2022)

Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation
por: De-Souza, Evandro A., et al.
Publicado: (2023)

Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR
por: de la Cruz‐Ruiz, Patricia, et al.
Publicado: (2021)

Mitochondrial dysfunction, UPR(mt) signaling, and targeted therapy in metastasis tumor
por: Keerthiga, Rajendiran, et al.
Publicado: (2021)

The mitochondrial unfolded protein response (UPR(mt)) protects against osteoarthritis
por: Zhou, Zhibin, et al.
Publicado: (2022)

UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication
por: Melber, Andrew, et al.
Publicado: (2018)

UPR(mt) activation improves pathological alterations in cellular models of mitochondrial diseases
por: Suárez-Rivero, Juan M., et al.
Publicado: (2022)

Role of UPR(mt) and mitochondrial dynamics in host immunity: it takes two to tango
por: Kumar, Manmohan, et al.
Publicado: (2023)

mtUPR Modulation as a Therapeutic Target for Primary and Secondary Mitochondrial Diseases
por: Cilleros-Holgado, Paula, et al.
Publicado: (2023)

Sensing the Stress: A Role for the UPR(mt) and UPR(am) in the Quality Control of Mitochondria
por: Callegari, Sylvie, et al.
Publicado: (2018)

Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR(mt) in the hypothalamus of mice
por: Braga, Renata R., et al.
Publicado: (2021)

The mitochondrial unfolded protein response (UPR(mt)): shielding against toxicity to mitochondria in cancer
por: Inigo, Joseph R., et al.
Publicado: (2022)

Beyond the cell factory: Homeostatic regulation of and by the UPR(ER)
por: Metcalf, Melissa G., et al.
Publicado: (2020)

Discovery of Genes Activated by the Mitochondrial Unfolded Protein Response (mtUPR) and Cognate Promoter Elements
por: Aldridge, Jonathan E., et al.
Publicado: (2007)

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis
por: Kenny, T C, et al.
Publicado: (2017)

SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension
por: Gao, Kaiyu, et al.
Publicado: (2019)

Mitochondria Retrograde Signaling and the UPR(mt): Where Are We in Mammals?
por: Arnould, Thierry, et al.
Publicado: (2015)

Genome-wide RNAi screen for regulators of UPR(mt) in Caenorhabditis elegans mutants with defects in mitochondrial fusion
por: Haeussler, Simon, et al.
Publicado: (2021)

Mitochondrial metabolites extend lifespan
por: Mishur, Robert J., et al.
Publicado: (2016)

Mitochondrial Inverted Repeats Strongly Correlate with Lifespan: mtDNA Inversions and Aging
por: Yang, Jiang-Nan, et al.
Publicado: (2013)

TLR22-Induced Pro-Apoptotic mtROS Abets UPR(mt)-Mediated Mitochondrial Fission in Aeromonas hydrophila-Infected Headkidney Macrophages of Clarias gariepinus
por: Kumar, Manmohan, et al.
Publicado: (2022)

A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR
por: Amin, Mustafi Raisa, et al.
Publicado: (2020)

Transient activation of the UPR(ER) is an essential step in the acquisition of pluripotency during reprogramming
por: Simic, Milos S., et al.
Publicado: (2019)

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
por: Siegmund, Stephanie E, et al.
Publicado: (2017)

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial UPR
por: Lin, Yi-Fan, et al.
Publicado: (2016)

Auraptene Enhances Junction Assembly in Cerebrovascular Endothelial Cells by Promoting Resilience to Mitochondrial Stress through Activation of Antioxidant Enzymes and mtUPR
por: Lee, Min Joung, et al.
Publicado: (2021)

Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
por: Ali, Levi, et al.
Publicado: (2020)

A cytosolic surveillance mechanism activates the mitochondrial UPR
por: Sutandy, F. X. Reymond, et al.
Publicado: (2023)

Physical exercise elicits UPR(mt) in the skeletal muscle: The role of c-Jun N-terminal kinase
por: Gaspar, Rodrigo Stellzer, et al.
Publicado: (2023)

The UPR for cytokinesis
por: LeBrasseur, Nicole
Publicado: (2007)

UPR-Mediated Membrane Biogenesis in B Cells
por: Brewer, Joseph W., et al.
Publicado: (2012)

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts
por: Pharaoh, Gavin, et al.
Publicado: (2016)

Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP(+) in human SH-SY5Y neuroblastoma cells
por: Cai, Yousheng, et al.
Publicado: (2020)

UPR Responsive Genes Manf and Xbp1 in Stroke
por: Lõhelaid, Helike, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4ccd116ouvktohqig4vujgce0i