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Characterization and Sequence Mapping of Large RNA and mRNA Therapeutics Using Mass Spectrometry

[Image: see text] Large RNA including mRNA (mRNA) has emerged as an important new class of therapeutics. Recently, this has been demonstrated by two highly efficacious vaccines based on mRNA sequences encoding for a modified version of the SARS-CoV-2 spike protein. There is currently significant dem...

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Detalles Bibliográficos
Autores principales: Vanhinsbergh, Christina J., Criscuolo, Angela, Sutton, Jennifer N., Murphy, Keeley, Williamson, Andrew J. K., Cook, Ken, Dickman, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134182/
https://www.ncbi.nlm.nih.gov/pubmed/35549087
http://dx.doi.org/10.1021/acs.analchem.2c00765