Cargando…

Discovery of Novel α-Carboline Inhibitors of the Anaplastic Lymphoma Kinase

[Image: see text] The anaplastic lymphoma kinase (ALK) is abnormally expressed and hyperactivated in a number of tumors and represents an ideal therapeutic target. Despite excellent clinical responses to ALK inhibition, drug resistance still represents an issue and novel compounds that overcome drug...

Descripción completa

Detalles Bibliográficos
Autores principales: Mologni, Luca, Tardy, Sébastien, Zambon, Alfonso, Orsato, Alexandre, Bisson, William H., Ceccon, Monica, Viltadi, Michela, D’Attoma, Joseph, Pannilunghi, Sara, Vece, Vito, Bertho, Jerome, Goekjian, Peter, Scapozza, Leonardo, Gambacorti-Passerini, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134258/
https://www.ncbi.nlm.nih.gov/pubmed/35647450
http://dx.doi.org/10.1021/acsomega.2c00507