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Discovery of Novel α-Carboline Inhibitors of the Anaplastic Lymphoma Kinase
[Image: see text] The anaplastic lymphoma kinase (ALK) is abnormally expressed and hyperactivated in a number of tumors and represents an ideal therapeutic target. Despite excellent clinical responses to ALK inhibition, drug resistance still represents an issue and novel compounds that overcome drug...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134258/ https://www.ncbi.nlm.nih.gov/pubmed/35647450 http://dx.doi.org/10.1021/acsomega.2c00507 |