New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

BACKGROUND: Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of human iCCA. Carcinogenic changes and therapeutic vulnerabilities in CCA may be captured by molecular investigations in bile,...

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Detalles Bibliográficos
Autores principales: Colyn, Leticia, Alvarez-Sola, Gloria, Latasa, M. Ujue, Uriarte, Iker, Herranz, Jose M., Arechederra, Maria, Vlachogiannis, George, Rae, Colin, Pineda-Lucena, Antonio, Casadei-Gardini, Andrea, Pedica, Federica, Aldrighetti, Luca, López-López, Angeles, López-Gonzálvez, Angeles, Barbas, Coral, Ciordia, Sergio, Van Liempd, Sebastiaan M., Falcón-Pérez, Juan M., Urman, Jesus, Sangro, Bruno, Vicent, Silve, Iraburu, Maria J., Prosper, Felipe, Nelson, Leonard J., Banales, Jesus M., Martinez-Chantar, Maria Luz, Marin, Jose J. G., Braconi, Chiara, Trautwein, Christian, Corrales, Fernando J., Cubero, F. Javier, Berasain, Carmen, Fernandez-Barrena, Maite G., Avila, Matias A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134609/
https://www.ncbi.nlm.nih.gov/pubmed/35619118
http://dx.doi.org/10.1186/s13046-022-02386-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134609/
https://www.ncbi.nlm.nih.gov/pubmed/35619118
http://dx.doi.org/10.1186/s13046-022-02386-2

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