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BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1

BACKGROUND: Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role in bone absorption. However, the mechanisms underlying the tight regulation of...

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Detalles Bibliográficos
Autores principales: Zhang, Yufeng, Yang, Min, Zhang, Sheng, Yang, Zhiqiang, Zhu, Yufan, Wang, Yi, Chen, Zhe, Lv, Xuan, Huang, Zan, Xie, Yuanlong, Cai, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134610/
https://www.ncbi.nlm.nih.gov/pubmed/35619122
http://dx.doi.org/10.1186/s13578-022-00813-7