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An in vivo accelerated developmental myelination model for testing promyelinating therapeutics

BACKGROUND: Therapeutic agents stimulating the process of myelination could be beneficial for the treatment of demyelinating diseases, such as multiple sclerosis. The efficient translation of compounds promoting myelination in vitro to efficacy in vivo is inherently time-consuming and expensive. Thy...

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Detalles Bibliográficos
Autores principales: Lariosa-Willingham, Karen, Leonoudakis, Dmitri, Bragge, Timo, Tolppanen, Laura, Nurmi, Antti, Flanagan, Megan, Gibson, Janelle, Wilson, David, Stratton, Jennifer, Lehtimäki, Kimmo K., Miszczuk, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134688/
https://www.ncbi.nlm.nih.gov/pubmed/35614392
http://dx.doi.org/10.1186/s12868-022-00714-y