A Positive Feedback Loop between Inactive VHL-Triggered Histone Lactylation and PDGFRβ Signaling Drives Clear Cell Renal Cell Carcinoma Progression

Inactive von Hippel-Lindau (VHL) is linked to metabolic reprogramming and plays pivotal roles in the pathogenesis of clear cell renal cell carcinoma (ccRCC). Here, we identify a previously unknown oncogenic role for inactive VHL in actively triggering histone lactylation to promote ccRCC progression...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jiefeng, Luo, Li, Zhao, Chongyu, Li, Xiyuan, Wang, Zimo, Zeng, Ziwei, Yang, Xin, Zheng, Xiaobin, Jie, Haiqing, Kang, Liang, Li, Shujuan, Liu, Shuang, Zhou, Chi, Liu, Huashan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134910/
https://www.ncbi.nlm.nih.gov/pubmed/35637958
http://dx.doi.org/10.7150/ijbs.73398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134910/
https://www.ncbi.nlm.nih.gov/pubmed/35637958
http://dx.doi.org/10.7150/ijbs.73398

Ejemplares similares