Direct Cardiac Actions of Sodium-Glucose Cotransporter 2 Inhibition Improve Mitochondrial Function and Attenuate Oxidative Stress in Pressure Overload-Induced Heart Failure

Clinical trials showed that sodium-glucose cotransporter 2 (SGLT2) inhibitors, a class of drugs developed for treating diabetes mellitus, improve prognosis of patients with heart failure (HF). However, the mechanisms for cardioprotection by SGLT2 inhibitors are still unclear. Mitochondrial dysfuncti...

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Detalles Bibliográficos
Autores principales: Li, Xuan, Flynn, Elizabeth R., do Carmo, Jussara M., Wang, Zhen, da Silva, Alexandre A., Mouton, Alan J., Omoto, Ana C. M., Hall, Michael E., Hall, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135142/
https://www.ncbi.nlm.nih.gov/pubmed/35647080
http://dx.doi.org/10.3389/fcvm.2022.859253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135142/
https://www.ncbi.nlm.nih.gov/pubmed/35647080
http://dx.doi.org/10.3389/fcvm.2022.859253

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