A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models

Test compounds used on in vitro model systems are conventionally delivered to cell culture wells as fixed concentration bolus doses; however, this poorly replicates the pharmacokinetic (PK) concentration changes seen in vivo and reduces the predictive value of the data. Herein, proof-of-concept expe...

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Detalles Bibliográficos
Autores principales: Singh, Dharaminder, Deosarkar, Sudhir P., Cadogan, Elaine, Flemington, Vikki, Bray, Alysha, Zhang, Jingwen, Reiserer, Ronald S., Schaffer, David K., Gerken, Gregory B., Britt, Clayton M., Werner, Erik M., Gibbons, Francis D., Kostrzewski, Tomasz, Chambers, Christopher E., Davies, Emma J., Montoya, Antonio Ramos, Fok, Jacqueline H. L., Hughes, David, Fabre, Kristin, Wagoner, Matthew P., Wikswo, John P., Scott, Clay W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135222/
https://www.ncbi.nlm.nih.gov/pubmed/35617197
http://dx.doi.org/10.1371/journal.pbio.3001624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135222/
https://www.ncbi.nlm.nih.gov/pubmed/35617197
http://dx.doi.org/10.1371/journal.pbio.3001624

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