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Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids

Tumors display rich cellular heterogeneity and typically consist of multiple co-existing clones with distinct genotypic and phenotypic characteristics. The acquisition of resistance to chemotherapy has been shown to contribute to the development of aggressive cancer traits, such as increased migrati...

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Detalles Bibliográficos
Autores principales: Thege, Fredrik I., Cardle, Ian I., Gruber, Conor N., Siemann, Megan J., Cong, Sophie, Wittmann, Katharina, Love, Justin, Kirby, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135276/
https://www.ncbi.nlm.nih.gov/pubmed/35617275
http://dx.doi.org/10.1371/journal.pone.0267882