Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells

Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) myofibroblasts are the primary cell type responsible for liver fibrosis, yet there are currently no therapies...

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Detalles Bibliográficos
Autores principales: Li, Wenyang, Chen, Jennifer Y, Sun, Cheng, Sparks, Robert P, Pantano, Lorena, Rahman, Raza-Ur, Moran, Sean P, Pondick, Joshua V, Kirchner, Rory, Wrobel, David, Bieler, Michael, Sauer, Achim, Ho Sui, Shannan J, Doerner, Julia F, Rippmann, Jörg F, Mullen, Alan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135407/
https://www.ncbi.nlm.nih.gov/pubmed/35617485
http://dx.doi.org/10.7554/eLife.74513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135407/
https://www.ncbi.nlm.nih.gov/pubmed/35617485
http://dx.doi.org/10.7554/eLife.74513

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