Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation

AXL, a TAM receptor tyrosine kinase (RTK), and its ligand growth arrest-specific 6 (GAS6) are implicated in cancer metastasis and drug resistance, and cellular entry of viruses. Given this, AXL is an attractive therapeutic target, and its inhibitors are being tested in cancer and COVID-19 clinical t...

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Detalles Bibliográficos
Autores principales: Poświata, Agata, Kozik, Kamila, Miączyńska, Marta, Zdżalik-Bielecka, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135597/
https://www.ncbi.nlm.nih.gov/pubmed/35622156
http://dx.doi.org/10.1007/s00018-022-04312-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135597/
https://www.ncbi.nlm.nih.gov/pubmed/35622156
http://dx.doi.org/10.1007/s00018-022-04312-3

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