A cross-species spatiotemporal proteomic analysis identifies UBE3A-dependent signaling pathways and targets

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A. Restoring UBE3A levels is a potential disease-modifying therapy for AS and has recently entered clinical trials. There is paucity of data regarding the molecular changes downstream of UBE3A...

Descripción completa

Detalles Bibliográficos
Autores principales: Pandya, Nikhil J., Meier, Sonja, Tyanova, Stefka, Terrigno, Marco, Wang, Congwei, Punt, A. Mattijs, Mientjes, E. J., Vautheny, Audrey, Distel, Ben, Kremer, Thomas, Elgersma, Ype, Jagasia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135630/
https://www.ncbi.nlm.nih.gov/pubmed/35264729
http://dx.doi.org/10.1038/s41380-022-01484-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135630/
https://www.ncbi.nlm.nih.gov/pubmed/35264729
http://dx.doi.org/10.1038/s41380-022-01484-z

Ejemplares similares