Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds

Hydroarylation of alkynes with unactivated C(sp(2))−H bonds via chelated C−H metalation mainly occurs at γ-position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β-C(sp(2))−H bond-involved hydroarylation has been a formidable challenge. Herein, we used a pho...

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Autores principales: Qi, Shao-Long, Liu, Yu-Peng, Li, Yi, Luan, Yu-Xin, Ye, Mengchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135730/
https://www.ncbi.nlm.nih.gov/pubmed/35618702
http://dx.doi.org/10.1038/s41467-022-30367-8
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author Qi, Shao-Long
Liu, Yu-Peng
Li, Yi
Luan, Yu-Xin
Ye, Mengchun
author_facet Qi, Shao-Long
Liu, Yu-Peng
Li, Yi
Luan, Yu-Xin
Ye, Mengchun
author_sort Qi, Shao-Long
collection PubMed
description Hydroarylation of alkynes with unactivated C(sp(2))−H bonds via chelated C−H metalation mainly occurs at γ-position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β-C(sp(2))−H bond-involved hydroarylation has been a formidable challenge. Herein, we used a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.
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spelling pubmed-91357302022-05-28 Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds Qi, Shao-Long Liu, Yu-Peng Li, Yi Luan, Yu-Xin Ye, Mengchun Nat Commun Article Hydroarylation of alkynes with unactivated C(sp(2))−H bonds via chelated C−H metalation mainly occurs at γ-position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β-C(sp(2))−H bond-involved hydroarylation has been a formidable challenge. Herein, we used a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle. Nature Publishing Group UK 2022-05-26 /pmc/articles/PMC9135730/ /pubmed/35618702 http://dx.doi.org/10.1038/s41467-022-30367-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qi, Shao-Long
Liu, Yu-Peng
Li, Yi
Luan, Yu-Xin
Ye, Mengchun
Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds
title Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds
title_full Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds
title_fullStr Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds
title_full_unstemmed Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds
title_short Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp(2))−H bonds
title_sort ni-catalyzed hydroarylation of alkynes with unactivated β-c(sp(2))−h bonds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135730/
https://www.ncbi.nlm.nih.gov/pubmed/35618702
http://dx.doi.org/10.1038/s41467-022-30367-8
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