The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases

The product template (PT) domains act as an aldol cyclase to control the regiospecific aldol cyclization of the extremely reactive poly-β-ketone intermediate assembled by an iterative type I polyketide synthases (PKSs). Up to now, only the structure of fungal PksA PT that mediates the first-ring cyc...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Yuanyuan, Yang, Xu, Ji, Huining, Deng, Zixin, Lin, Shuangjun, Zheng, Jianting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135731/
https://www.ncbi.nlm.nih.gov/pubmed/35618872
http://dx.doi.org/10.1038/s42003-022-03477-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135731/
https://www.ncbi.nlm.nih.gov/pubmed/35618872
http://dx.doi.org/10.1038/s42003-022-03477-8

Ejemplares similares