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Two Pituitary Neuroendocrine Tumors (PitNETs) with Very High Proliferation and TP53 Mutation — High-Grade PitNET or PitNEC?

We report two pituitary neuroendocrine tumors (PitNETs) with very high Ki67 labeling indices, many mitoses and TP53 mutation (nearly all tumor cell nuclei were positive for p53). One of the tumors had bone and liver metastases. One was a corticotroph cell tumor; the other was a lactotroph tumor. The...

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Detalles Bibliográficos
Autores principales: Saeger, Wolfgang, Mawrin, Christian, Meinhardt, Matthias, Wefers, Annika K., Jacobsen, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135791/
https://www.ncbi.nlm.nih.gov/pubmed/34669159
http://dx.doi.org/10.1007/s12022-021-09693-y