Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels

The rs2802292, rs2764264 and rs13217795 variants of FOXO3 have been associated with extreme longevity in multiple human populations, but the mechanisms underpinning this remain unclear. We aimed to characterise potential effects of longevity-associated variation on the expression and mRNA processing...

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Detalles Bibliográficos
Autores principales: Frankum, Ryan, Jameson, Tom S. O., Knight, Bridget A., Stephens, Francis B., Wall, Benjamin T., Donlon, Timothy A., Torigoe, Trevor, Willcox, Bradley J., Willcox, D. Craig, Allsopp, Richard C., Harries, Lorna W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135902/
https://www.ncbi.nlm.nih.gov/pubmed/34436732
http://dx.doi.org/10.1007/s11357-021-00431-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135902/
https://www.ncbi.nlm.nih.gov/pubmed/34436732
http://dx.doi.org/10.1007/s11357-021-00431-0

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