PTCH1-null induced pluripotent stem cells exclusively differentiate into immature ectodermal cells with large areas of medulloblastoma-like tissue

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder with an increased incidence of tumors, such as basal cell carcinomas and medulloblastomas. The PTCH1 gene, responsible for NBCCS, suppresses the hedgehog signaling pathway, which is recognized as one of the important path...

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Detalles Bibliográficos
Autores principales: Nagao, Kazuaki, Kato, Chise, Ikemoto, Yu, Motojima, Toshino, Fujii, Katsunori, Umezawa, Akihiro, Miyashita, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135936/
https://www.ncbi.nlm.nih.gov/pubmed/35618979
http://dx.doi.org/10.1007/s12672-022-00498-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135936/
https://www.ncbi.nlm.nih.gov/pubmed/35618979
http://dx.doi.org/10.1007/s12672-022-00498-x

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