DNA damage-induced degradation of Sp1 promotes cellular senescence

Persistent DNA damage (genotoxic stress) triggers signaling cascades that drive cells into apoptosis or senescence to avoid replicating a damaged genome. Sp1 has been found to play a role in double strand break (DSB) repair, and a link between Sp1 and aging has also been established, where Sp1 prote...

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Detalles Bibliográficos
Autores principales: Swift, Michelle L., Sell, Christian, Azizkhan-Clifford, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135943/
https://www.ncbi.nlm.nih.gov/pubmed/34550526
http://dx.doi.org/10.1007/s11357-021-00456-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135943/
https://www.ncbi.nlm.nih.gov/pubmed/34550526
http://dx.doi.org/10.1007/s11357-021-00456-5

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