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DNA damage-induced degradation of Sp1 promotes cellular senescence

Persistent DNA damage (genotoxic stress) triggers signaling cascades that drive cells into apoptosis or senescence to avoid replicating a damaged genome. Sp1 has been found to play a role in double strand break (DSB) repair, and a link between Sp1 and aging has also been established, where Sp1 prote...

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Detalles Bibliográficos
Autores principales:	Swift, Michelle L., Sell, Christian, Azizkhan-Clifford, Jane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135943/ https://www.ncbi.nlm.nih.gov/pubmed/34550526 http://dx.doi.org/10.1007/s11357-021-00456-5

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