Neuroprotective Effect of E3 Ubiquitin Ligase RNF8 Against Ischemic Stroke via HDAC2 Stability Reduction and Reelin-Dependent GSK3β Inhibition

Loss of E3 ubiquitin ligase RING finger protein 8 (RNF8) may lead to neuronal DNA damage and apoptosis. In order to expand on our knowledge on the mechanistic basis underlying neuronal death in ischemic stroke, the present study sought to investigate the potential role of E3 ubiquitin ligase RNF8 on...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaoxi, Li, Junxiang, You, Dengwei, Xiao, Yan, Huang, Zhi, Yu, Wenfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135995/
https://www.ncbi.nlm.nih.gov/pubmed/35622272
http://dx.doi.org/10.1007/s12035-022-02880-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135995/
https://www.ncbi.nlm.nih.gov/pubmed/35622272
http://dx.doi.org/10.1007/s12035-022-02880-w

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