Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice

Activation of intravesical PAR4 receptors leads to bladder hyperalgesia (BHA) through release of urothelial macrophage migration inhibitory factor (MIF) and urothelial high mobility group box-1 (HMGB1). MIF deficiency and/or MIF antagonism at the bladder block BHA in mice yet the mechanisms are not...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Shaojing, Ma, Fei, Mahmood, Dlovan F. D., Meyer-Siegler, Katherine L., Leng, Lin, Bucala, Richard, Vera, Pedro L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135998/
https://www.ncbi.nlm.nih.gov/pubmed/35645739
http://dx.doi.org/10.3389/fnsys.2022.882493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135998/
https://www.ncbi.nlm.nih.gov/pubmed/35645739
http://dx.doi.org/10.3389/fnsys.2022.882493

Ejemplares similares