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Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice

Activation of intravesical PAR4 receptors leads to bladder hyperalgesia (BHA) through release of urothelial macrophage migration inhibitory factor (MIF) and urothelial high mobility group box-1 (HMGB1). MIF deficiency and/or MIF antagonism at the bladder block BHA in mice yet the mechanisms are not...

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Detalles Bibliográficos
Autores principales:	Ye, Shaojing, Ma, Fei, Mahmood, Dlovan F. D., Meyer-Siegler, Katherine L., Leng, Lin, Bucala, Richard, Vera, Pedro L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9135998/ https://www.ncbi.nlm.nih.gov/pubmed/35645739 http://dx.doi.org/10.3389/fnsys.2022.882493

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