Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus in pancreatic ductal adenocarcinoma (PDA). To determine the interplay between oncogenic KRas and nuclear GSK-3β in PDA development, we generated Lox-STOP-Lox (LSL) nuclear-targeted GSK-3β...

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Detalles Bibliográficos
Autores principales: Ding, Li, Roeck, Kaely, Zhang, Cheng, Zidek, Brooke, Rodman, Esther, Hernandez-Barco, Yasmin, Zhang, Jin-San, Bamlet, William, Oberg, Ann, Zhang, Lizhi, Bardeesy, Nabeel, Li, Hu, Billadeau, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136019/
https://www.ncbi.nlm.nih.gov/pubmed/35646902
http://dx.doi.org/10.3389/fcell.2022.853003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136019/
https://www.ncbi.nlm.nih.gov/pubmed/35646902
http://dx.doi.org/10.3389/fcell.2022.853003

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