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Active Expression of Human Hyaluronidase PH20 and Characterization of Its Hydrolysis Pattern

Hyaluronidases are a group of glycosidases catalyzing the degradation of hyaluronic acid (HA). Because of the advantages of effectively hydrolyzing the HA-rich matrix and low immunogenicity, human hyaluronidase PH20 (hPH20) is widely used in the medical field. Here, we realized the active expression...

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Detalles Bibliográficos
Autores principales: Pang, Bo, He, Jing, Zhang, Weijiao, Huang, Hao, Wang, Yang, Wang, Miao, Du, Guocheng, Kang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136067/
https://www.ncbi.nlm.nih.gov/pubmed/35646856
http://dx.doi.org/10.3389/fbioe.2022.885888