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Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase
The posttranslational regulation of the neuronal proteome is critical for brain homeostasis but becomes dysregulated in the aged or diseased brain, in which abnormal posttranslational modifications (PTMs) are frequently observed. While the full extent of modified substrates that comprise the “PTM-om...
Autores principales: | Tabassum, Zarin, Tseng, Jui-Heng, Isemann, Camryn, Tian, Xu, Chen, Youjun, Herring, Laura E., Cohen, Todd J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136110/ https://www.ncbi.nlm.nih.gov/pubmed/35469920 http://dx.doi.org/10.1016/j.jbc.2022.101977 |
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