RNA modifications can affect RNase H1-mediated PS-ASO activity

Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1. Target reduction through this mechanism is influenced by numerous features of the RNA, which modulate PS-ASO binding affinities to the R...

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Detalles Bibliográficos
Autores principales: Doxtader Lacy, Katelyn A., Liang, Xue-hai, Zhang, Lingdi, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136273/
https://www.ncbi.nlm.nih.gov/pubmed/35664704
http://dx.doi.org/10.1016/j.omtn.2022.05.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136273/
https://www.ncbi.nlm.nih.gov/pubmed/35664704
http://dx.doi.org/10.1016/j.omtn.2022.05.024

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