One-step synthesis of site-specific antibody–drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates

Glycosite-specific antibody‒drug conjugatess (gsADCs), harnessing Asn297 N-glycan of IgG Fc as the conjugation site for drug payloads, usually require multi-step glycoengineering with two or more enzymes, which limits the substrate diversification and complicates the preparation process. Herein, we...

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Detalles Bibliográficos
Autores principales: Shi, Wei, Li, Wanzhen, Zhang, Jianxin, Li, Tiehai, Song, Yakai, Zeng, Yue, Dong, Qian, Lin, Zeng, Gong, Likun, Fan, Shuquan, Tang, Feng, Huang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136568/
https://www.ncbi.nlm.nih.gov/pubmed/35646546
http://dx.doi.org/10.1016/j.apsb.2021.12.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136568/
https://www.ncbi.nlm.nih.gov/pubmed/35646546
http://dx.doi.org/10.1016/j.apsb.2021.12.013

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