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Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex (TRiC) contains eight para...
Autores principales: | Wang, Gan, Zhang, Min, Meng, Ping, Long, Chengbo, Luo, Xiaodong, Yang, Xingwei, Wang, Yunfei, Zhang, Zhiye, Mwangi, James, Kamau, Peter Muiruri, Dai, Zhi, Ke, Zunfu, Zhang, Yi, Chen, Wenlin, Zhao, Xudong, Ge, Fei, Lv, Qiumin, Rong, Mingqiang, Li, Dongsheng, Jin, Yang, Sheng, Xia, Lai, Ren |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136613/ https://www.ncbi.nlm.nih.gov/pubmed/35646538 http://dx.doi.org/10.1016/j.apsb.2021.12.024 |
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