Cargando…
Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning
Head and neck squamous cell carcinoma (HNSCC) is one of the most common human cancers; however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map (cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and s...
Autores principales: | Liang, Dong, Yu, Chen, Ma, Zhao, Yang, Xingye, Li, Zhenzhen, Dong, Xuhui, Qin, Xiaojun, Du, Lupei, Li, Minyong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136614/ https://www.ncbi.nlm.nih.gov/pubmed/35646536 http://dx.doi.org/10.1016/j.apsb.2021.12.005 |
Ejemplares similares
-
The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer
por: Florio, Rosalba, et al.
Publicado: (2019) -
Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120
por: Ma, Siyue, et al.
Publicado: (2022) -
First small-molecule PROTACs for G protein-coupled receptors: inducing α(1A)-adrenergic receptor degradation
por: Li, Zhenzhen, et al.
Publicado: (2020) -
Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
por: Nygren, Peter, et al.
Publicado: (2013) -
Repositioning salicylanilide anthelmintic drugs to treat adenovirus infections
por: Marrugal-Lorenzo, José A., et al.
Publicado: (2019)