Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

The protein TRIM5α has multiple roles in antiretroviral defense, but the mechanisms underlying TRIM5α action are unclear. Here, we employ APEX2-based proteomics to identify TRIM5α-interacting partners. Our proteomics results connect TRIM5 to other proteins with actions in antiviral defense. Addition...

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Detalles Bibliográficos
Autores principales: Saha, Bhaskar, Salemi, Michelle, Williams, Geneva L., Oh, Seeun, Paffett, Michael L., Phinney, Brett, Mandell, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136943/
https://www.ncbi.nlm.nih.gov/pubmed/35545034
http://dx.doi.org/10.1016/j.celrep.2022.110797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136943/
https://www.ncbi.nlm.nih.gov/pubmed/35545034
http://dx.doi.org/10.1016/j.celrep.2022.110797

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