AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p

BACKGROUND: AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. Here, we set out to determine the relevance of AP4 in human colorectal cancer (CRC) cells. METHODS: A CRISPR/Cas9 approach w...

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Detalles Bibliográficos
Autores principales: Chou, Jinjiang, Kaller, Markus, Jaeckel, Stephanie, Rokavec, Matjaz, Hermeking, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137087/
https://www.ncbi.nlm.nih.gov/pubmed/35624466
http://dx.doi.org/10.1186/s12943-022-01581-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137087/
https://www.ncbi.nlm.nih.gov/pubmed/35624466
http://dx.doi.org/10.1186/s12943-022-01581-1

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