Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability

BACKGROUND: Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely associated with multiple myeloma (MM) progression and drug resistance. Thereby, targeting c-Myc is expected to be a useful therapeutic strategy for hemat...

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Detalles Bibliográficos
Autores principales: Yao, Ruosi, Zhang, Menghui, Zhou, Jian, Liu, Linlin, Zhang, Yan, Gao, Jian, Xu, Kailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137135/
https://www.ncbi.nlm.nih.gov/pubmed/35619182
http://dx.doi.org/10.1186/s12964-022-00868-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137135/
https://www.ncbi.nlm.nih.gov/pubmed/35619182
http://dx.doi.org/10.1186/s12964-022-00868-6

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