DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, in which P-glycoprotein (P-gp) is overexpressed and the PI3K/Akt signaling pathway is dysregulated. Previously, we designed and synthesized DHW-221, a dual PI3K/mTOR...

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Detalles Bibliográficos
Autores principales: Liu, Mingyue, Xu, Chang, Qin, Xiaochun, Liu, Wenwu, Li, Deping, Jia, Hui, Gao, Xudong, Wu, Yuting, Wu, Qiong, Xu, Xiangbo, Xing, Bo, Jiang, Xiaowen, Lu, Hongyuan, Zhang, Yingshi, Ding, Huaiwei, Zhao, Qingchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137409/
https://www.ncbi.nlm.nih.gov/pubmed/35646704
http://dx.doi.org/10.3389/fonc.2022.873649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137409/
https://www.ncbi.nlm.nih.gov/pubmed/35646704
http://dx.doi.org/10.3389/fonc.2022.873649

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