Cargando…

DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, in which P-glycoprotein (P-gp) is overexpressed and the PI3K/Akt signaling pathway is dysregulated. Previously, we designed and synthesized DHW-221, a dual PI3K/mTOR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Mingyue, Xu, Chang, Qin, Xiaochun, Liu, Wenwu, Li, Deping, Jia, Hui, Gao, Xudong, Wu, Yuting, Wu, Qiong, Xu, Xiangbo, Xing, Bo, Jiang, Xiaowen, Lu, Hongyuan, Zhang, Yingshi, Ding, Huaiwei, Zhao, Qingchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137409/ https://www.ncbi.nlm.nih.gov/pubmed/35646704 http://dx.doi.org/10.3389/fonc.2022.873649

Ejemplares similares

Dual blocking of PI3K and mTOR signaling by DHW‐221, a novel benzimidazole derivative, exerts antitumor activity in human non‐small cell lung cancer
por: Qin, Xiaochun, et al.
Publicado: (2021)

A novel 4-aminoquinazoline derivative, DHW-208, suppresses the growth of human breast cancer cells by targeting the PI3K/AKT/mTOR pathway
por: Wang, Shu, et al.
Publicado: (2020)

DHW-208, A Novel Phosphatidylinositol 3-Kinase (PI3K) Inhibitor, Has Anti-Hepatocellular Carcinoma Activity Through Promoting Apoptosis and Inhibiting Angiogenesis
por: Wang, Shu, et al.
Publicado: (2022)

ZDQ-0620, a Novel Phosphatidylinositol 3-Kinase Inhibitor, Inhibits Colorectal Carcinoma Cell Proliferation and Suppresses Angiogenesis by Attenuating PI3K/AKT/mTOR Pathway
por: Qin, Xiaochun, et al.
Publicado: (2022)

Potential Savings in DHW Facilities through the Use of Solar Thermal Energy in the Hospitals of Extremadura (Spain)
por: Sánchez-Barroso, Gonzalo, et al.
Publicado: (2020)

PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma
por: Hanna, Jason A., et al.
Publicado: (2018)

MicroRNA-221-3p Plays an Oncogenic Role in Gastric Carcinoma by Inhibiting PTEN Expression
por: Shi, Jianping, et al.
Publicado: (2017)

miR‐221‐3p regulates apoptosis of ovarian granulosa cells via targeting FOXO1 in older women with diminished ovarian reserve (DOR)
por: Wei, Chaofeng, et al.
Publicado: (2021)

Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
por: Broderick, Peter, et al.
Publicado: (2011)

P‐Glycoprotein (P‐gp)/ABCB1 plays a functional role in extravillous trophoblast (EVT) invasion and is decreased in the pre‐eclamptic placenta
por: Dunk, Caroline E., et al.
Publicado: (2018)

Malaria in pregnancy regulates P‐glycoprotein (P‐gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac
por: Martinelli, Lilian M., et al.
Publicado: (2020)

Pharmacokinetics, tissue distribution, and antitumor activity of a novel compound, NY-2, in non-small cell lung cancer
por: Zhang, Yingshi, et al.
Publicado: (2023)

Down-Regulated Exosomal MicroRNA-221 – 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair
por: Sun, Ling, et al.
Publicado: (2020)

5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells
por: Żesławska, Ewa, et al.
Publicado: (2022)

CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells
por: Zhang, Lei, et al.
Publicado: (2022)

Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites
por: F. Martins, Margarida L., et al.
Publicado: (2022)

The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype
por: Zhou, Yuntao, et al.
Publicado: (2018)

MiR‐221‐3p and miR‐92a‐3p enhances smoking‐induced inflammation in COPD
por: Shen, Yahui, et al.
Publicado: (2021)

P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp(high) cells and correlates with HIV-1 viral load
por: Minuesa, Gerard, et al.
Publicado: (2016)

MicroRNAs 218a-5p, 219a-5p, and 221-3p regulate vestibular compensation
por: Chang, Mun Young, et al.
Publicado: (2017)

Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis
por: Xu, Xiaoyuan, et al.
Publicado: (2023)

miR-221-3p Delivered by BMMSC-Derived Microvesicles Promotes the Development of Acute Myelocytic Leukemia
por: Zhang, Xuewu, et al.
Publicado: (2020)

Signaling Modulation by miRNA-221-3p During Tooth Morphogenesis in Mice
por: Aryal, Yam Prasad, et al.
Publicado: (2021)

Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma
por: Walsh, Naomi, et al.
Publicado: (2009)

The lncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/β-Catenin Signaling Pathway
por: Chen, Zhaolin, et al.
Publicado: (2020)

Which Is the Most Appropriate PI3K Inhibitor for Breast Cancer Patients with or without PIK3CA Status Mutant? A Systematic Review and Network Meta-Analysis
por: Wang, Shu, et al.
Publicado: (2020)

P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport
por: Seelig, Anna, et al.
Publicado: (2023)

Bioinformatics analysis of the expression and role of microRNA-221-3p in head and neck squamous cell carcinoma
por: Zhou, Ziyan, et al.
Publicado: (2021)

Environmental and Health Impacts of Domestic Hot Water (DHW) Boilers in Urban Areas: A Case Study from Turin, NW Italy
por: Ravina, Marco, et al.
Publicado: (2020)

Lobular Distribution and Variability in Hepatic ATP Binding Cassette Protein B1 (ABCB1, P-gp): Ontogenetic Differences and Potential for Toxicity
por: Abanda, Ngu Njei, et al.
Publicado: (2017)

MicroRNA-221-3p Targets THBS1 to Promote Wound Healing in Diabetes
por: Hu, Keyan, et al.
Publicado: (2023)

Polysaccharides Produced by the Mushroom Trametes robiniophila Murr Boosts the Sensitivity of Hepatoma Cells to Oxaliplatin via the miR-224-5p/ABCB1/P-gp Axis
por: Gou, Yudong, et al.
Publicado: (2022)

P-gp and taxanes
por: Hendrikx, Jeroen J.M.A., et al.
Publicado: (2014)

Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis
por: Li, Jin, et al.
Publicado: (2020)

Long non-coding RNA X-inactive specific transcript suppresses the progression of hepatocellular carcinoma through microRNA-221-3p-targeted regulation of O6-methylguanine-DNA methyltransferase
por: Chen, Zushun, et al.
Publicado: (2022)

miR-221-3p promotes the cell growth of non-small cell lung cancer by targeting p27
por: Yin, Guoqing, et al.
Publicado: (2019)

GAS5 regulates diabetic cardiomyopathy via miR-221-3p/p27 axis-associated autophagy
por: Chen, Dezhi, et al.
Publicado: (2021)

Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity
por: Singh, Kuljeet, et al.
Publicado: (2021)

miR-140-3p enhances the sensitivity of LUAD cells to antitumor agents by targeting the ADAM10/Notch pathway
por: Meng, Hao, et al.
Publicado: (2022)

Plasma microRNA-221-3p as a biomarker for POCD after non-cardiac surgery
por: Fan, Di, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2joo803hnoesrb14ejk0irgvkt