Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

Malignant tumors exhibit altered metabolism resulting in a highly acidic extracellular microenvironment. Here, we show that cytoplasmic lipid droplet (LD) accumulation, indicative of a lipogenic phenotype, is a cellular adaption to extracellular acidity. LD marker PLIN2 is strongly associated with p...

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Detalles Bibliográficos
Autores principales: Pillai, Smitha, Mahmud, Iqbal, Mahar, Rohit, Griffith, Crystal, Langsen, Michael, Nguyen, Jonathan, Wojtkowiak, Jonathan W., Swietach, Pawel, Gatenby, Robert A., Bui, Marilyn M., Merritt, Matthew E., McDonald, Patricia, Garrett, Timothy J., Gillies, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137419/
https://www.ncbi.nlm.nih.gov/pubmed/35545051
http://dx.doi.org/10.1016/j.celrep.2022.110796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137419/
https://www.ncbi.nlm.nih.gov/pubmed/35545051
http://dx.doi.org/10.1016/j.celrep.2022.110796

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