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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
Malignant tumors exhibit altered metabolism resulting in a highly acidic extracellular microenvironment. Here, we show that cytoplasmic lipid droplet (LD) accumulation, indicative of a lipogenic phenotype, is a cellular adaption to extracellular acidity. LD marker PLIN2 is strongly associated with p...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137419/ https://www.ncbi.nlm.nih.gov/pubmed/35545051 http://dx.doi.org/10.1016/j.celrep.2022.110796 |