Cargando…

Computational Design of Inhibitors Targeting the Catalytic β Subunit of Escherichia coli F(O)F(1)-ATP Synthase

With the uncontrolled growth of multidrug-resistant bacteria, there is an urgent need to search for new therapeutic targets, to develop drugs with novel modes of bactericidal action. FoF1-ATP synthase plays a crucial role in bacterial bioenergetic processes, and it has emerged as an attractive antim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Avila-Barrientos, Luis Pablo, Cofas-Vargas, Luis Fernando, Agüero-Chapin, Guillermin, Hernández-García, Enrique, Ruiz-Carmona, Sergio, Valdez-Cruz, Norma A., Trujillo-Roldán, Mauricio, Weber, Joachim, Ruiz-Blanco, Yasser B., Barril, Xavier, García-Hernández, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138118/ https://www.ncbi.nlm.nih.gov/pubmed/35625201 http://dx.doi.org/10.3390/antibiotics11050557

Ejemplares similares

Exploring the druggability of the binding site of aurovertin, an exogenous allosteric inhibitor of F(O)F(1)-ATP synthase
por: Cofas-Vargas, Luis Fernando, et al.
Publicado: (2022)

Exploring general-purpose protein features for distinguishing enzymes and non-enzymes within the twilight zone
por: Ruiz-Blanco, Yasser B., et al.
Publicado: (2017)

Efficient ATP synthesis by thermophilic Bacillus F(o)F(1)-ATP synthase
por: Soga, Naoki, et al.
Publicado: (2011)

Rotary catalysis of F(o)F(1)-ATP synthase
por: Watanabe, Rikiya
Publicado: (2013)

F(1)F(O) ATP synthase molecular motor mechanisms
por: Frasch, Wayne D., et al.
Publicado: (2022)

Structure of the ATP synthase catalytic complex (F(1)) from Escherichia coli in an auto-inhibited conformation
por: Cingolani, Gino, et al.
Publicado: (2011)

F-Type ATP Synthase Assembly Factors Atp11 and Atp12 in Arabidopsis
por: Duan, Zhikun, et al.
Publicado: (2020)

Unusual features of the c-ring of F(1)F(O) ATP synthases
por: Vlasov, A. V., et al.
Publicado: (2019)

Overview of fungal terpene synthases and their regulation
por: González-Hernández, Ricardo A., et al.
Publicado: (2023)

Metabolic Trade-offs in Yeast are Caused by F1F0-ATP synthase
por: Nilsson, Avlant, et al.
Publicado: (2016)

A mitochondrial megachannel resides in monomeric F(1)F(O) ATP synthase
por: Mnatsakanyan, Nelli, et al.
Publicado: (2019)

The mitochondrial Hsp70 controls the assembly of the F(1)F(O)-ATP synthase
por: Song, Jiyao, et al.
Publicado: (2023)

F(1)·F(o) ATP Synthase/ATPase: Contemporary View on Unidirectional Catalysis
por: Zharova, Tatyana V., et al.
Publicado: (2023)

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase
por: Kundu, Subhashri, et al.
Publicado: (2016)

Possible Involvement of F1F0-ATP synthase and Intracellular ATP in Keratinocyte Differentiation in normal skin and skin lesions
por: Xiaoyun, Xie, et al.
Publicado: (2017)

Changes within the central stalk of E. coli F(1)F(o) ATP synthase observed after addition of ATP
por: Sobti, Meghna, et al.
Publicado: (2023)

Mechanism of ADP-Inhibited ATP Hydrolysis in Single Proton-Pumping F(o)F(1)-ATP Synthase Trapped in Solution
por: Pérez, Iván, et al.
Publicado: (2023)

INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules
por: Naumenko, Nataliia, et al.
Publicado: (2017)

Reversible optical control of F(1)F(o)‐ATP synthase using photoswitchable inhibitors
por: Eisel, Bianca, et al.
Publicado: (2018)

Inorganic polyphosphate is produced and hydrolyzed in F(0)F(1)-ATP synthase of mammalian mitochondria
por: Baev, Artyom Y., et al.
Publicado: (2020)

The δ subunit of F(1)F(o)-ATP synthase is required for pathogenicity of Candida albicans
por: Li, Shuixiu, et al.
Publicado: (2021)

ABP-Finder: A Tool to Identify Antibacterial Peptides and the Gram-Staining Type of Targeted Bacteria
por: Ruiz-Blanco, Yasser B., et al.
Publicado: (2022)

Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment
por: Valdez-Cruz, Norma A., et al.
Publicado: (2021)

HtrA2 deficiency causes mitochondrial uncoupling through the F(1)F(0)-ATP synthase and consequent ATP depletion
por: Plun-Favreau, H, et al.
Publicado: (2012)

Structural Asymmetry and Kinetic Limping of Single Rotary F-ATP Synthases
por: Sielaff, Hendrik, et al.
Publicado: (2019)

A New Type of Proton Coordination in an F(1)F(o)-ATP Synthase Rotor Ring
por: Preiss, Laura, et al.
Publicado: (2010)

An alternative role of F(o)F(1)-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate
por: Gigliobianco, Tiziana, et al.
Publicado: (2013)

Visualizing Mitochondrial F(o)F(1)-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423
por: Starke, Ilka, et al.
Publicado: (2018)

Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F(1)F(0)-ATP synthase
por: Almendro-Vedia, Víctor G., et al.
Publicado: (2017)

Rotational Mechanism of F(O) Motor in the F-Type ATP Synthase Driven by the Proton Motive Force
por: Kubo, Shintaroh, et al.
Publicado: (2022)

Modulation of the H(+)/ATP coupling ratio by ADP and ATP as a possible regulatory feature in the F-type ATP synthases
por: Turina, Paola
Publicado: (2022)

The phototroph-specific β-hairpin structure of the γ subunit of F(o)F(1)-ATP synthase is important for efficient ATP synthesis of cyanobacteria
por: Kondo, Kumiko, et al.
Publicado: (2021)

Phosphorus Chemistry at the Roots of Bioenergetics: Ligand Permutation as the Molecular Basis of the Mechanism of ATP Synthesis/Hydrolysis by F(O)F(1)-ATP Synthase
por: Nath, Sunil
Publicado: (2023)

Surveying alignment-free features for Ortholog detection in related yeast proteomes by using supervised big data classifiers
por: Galpert, Deborah, et al.
Publicado: (2018)

The F(0)F(1)-ATP Synthase Complex Contains Novel Subunits and Is Essential for Procyclic Trypanosoma brucei
por: Zíková, Alena, et al.
Publicado: (2009)

Correction: A New Type of Proton Coordination in an F(1)F(o)-ATP Synthase Rotor Ring
por: Preiss, Laura, et al.
Publicado: (2010)

Correction: A New Type of Proton Coordination in an F(1)F(o)-ATP Synthase Rotor Ring
por: Preiss, Laura, et al.
Publicado: (2010)

The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F(1)F(o)-ATP synthase in cristae formation
por: Rampelt, Heike, et al.
Publicado: (2017)

Cooperation among c-subunits of F(o)F(1)-ATP synthase in rotation-coupled proton translocation
por: Mitome, Noriyo, et al.
Publicado: (2022)

Mitochondrial F(1)F(O) ATP synthase determines the local proton motive force at cristae rims
por: Rieger, Bettina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8ureqpgrtn1u6ta6q73fpdehib