Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability

The development of peptide inhibitors against intracellular targets depends upon the dual challenge of achieving a high affinity and specificity for the target and maintaining cellular permeability for biological activity. Previous efforts to develop bicyclic peptides targeted to the Grb7 signalling...

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Detalles Bibliográficos
Autores principales: Sturre, Natasha P., Colson, Rhys N., Shah, Neelam, Watson, Gabrielle M., Yang, Xue, Wilce, Matthew C. J., Price, John T., Wilce, Jacqueline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138261/
https://www.ncbi.nlm.nih.gov/pubmed/35625882
http://dx.doi.org/10.3390/biomedicines10051145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138261/
https://www.ncbi.nlm.nih.gov/pubmed/35625882
http://dx.doi.org/10.3390/biomedicines10051145

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