The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach

RIPK1 (receptor-interacting serine/threonine-protein kinase 1) enzymatic activity drives both apoptosis and necroptosis, a regulated form of necrosis. Because necroptosis is involved in necrotic core development in atherosclerotic plaques, we investigated the effects of a RIPK1(S25D/S25D) mutation,...

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Detalles Bibliográficos
Autores principales: Puylaert, Pauline, Coornaert, Isabelle, Neutel, Cédric H. G., Dondelinger, Yves, Delanghe, Tom, Bertrand, Mathieu J. M., Guns, Pieter-Jan, De Meyer, Guido R. Y., Martinet, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138372/
https://www.ncbi.nlm.nih.gov/pubmed/35625752
http://dx.doi.org/10.3390/biomedicines10051016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138372/
https://www.ncbi.nlm.nih.gov/pubmed/35625752
http://dx.doi.org/10.3390/biomedicines10051016

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