Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease

5-hydroxyfurfural (5HMF), an allosteric effector of hemoglobin (Hb) with an ability to increase Hb affinity for oxygen has been studied extensively for its antisickling effect in vitro and in vivo, and in humans for the treatment of sickle cell disease (SCD). One of the downstream pathophysiologies...

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Detalles Bibliográficos
Autores principales: Alhashimi, Rana T., Ghatge, Mohini S., Donkor, Akua K., Deshpande, Tanvi M., Anabaraonye, Nancy, Alramadhani, Dina, Danso-Danquah, Richmond, Huang, Boshi, Zhang, Yan, Musayev, Faik N., Abdulmalik, Osheiza, Safo, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138457/
https://www.ncbi.nlm.nih.gov/pubmed/35625623
http://dx.doi.org/10.3390/biom12050696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138457/
https://www.ncbi.nlm.nih.gov/pubmed/35625623
http://dx.doi.org/10.3390/biom12050696

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