Hinokiflavone Inhibits MDM2 Activity by Targeting the MDM2-MDMX RING Domain

SIMPLE SUMMARY: MDM2 is a ubiquitin E3 ligase, frequently overexpressed in human cancers. A biflavonoid Hinokiflavone was identified by virtual screening to bind the MDM2-MDMX RING domain and inhibit MDM2 E3 ligase activity. Hinokiflavone was shown to downregulate MDM2 and its homolog protein MDMX a...

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Detalles Bibliográficos
Autores principales: Ilic, Viktoria K., Egorova, Olga, Tsang, Ernest, Gatto, Milena, Wen, Yi, Zhao, Yong, Sheng, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138535/
https://www.ncbi.nlm.nih.gov/pubmed/35625571
http://dx.doi.org/10.3390/biom12050643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138535/
https://www.ncbi.nlm.nih.gov/pubmed/35625571
http://dx.doi.org/10.3390/biom12050643

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