Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice

Gasdermin D (GSDMD) is the key executor of pyroptotic cell death. Recent studies suggest that GSDMD-mediated pyroptosis is involved in atherosclerotic plaque destabilization. We report that cleaved GSDMD is expressed in macrophage- and smooth muscle cell-rich areas of human plaques. To determine the...

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Detalles Bibliográficos
Autores principales: Puylaert, Pauline, Van Praet, Melissa, Vaes, Frederik, Neutel, Cédric H. G., Roth, Lynn, Guns, Pieter-Jan, De Meyer, Guido R. Y., Martinet, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138554/
https://www.ncbi.nlm.nih.gov/pubmed/35625908
http://dx.doi.org/10.3390/biomedicines10051171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138554/
https://www.ncbi.nlm.nih.gov/pubmed/35625908
http://dx.doi.org/10.3390/biomedicines10051171

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