C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice

The non-coding GGGGCC hexanucleotide repeat expansion (HRE) in C9orf72 gene is a dominant cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This intronic mutation elicits the formation of nuclear and cytoplasmic inclusions containing RNA, RNA-binding proteins, and HRE-d...

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Detalles Bibliográficos
Autores principales: Hatanaka, Yukari, Umeda, Tomohiro, Shigemori, Keiko, Takeuchi, Toshihide, Nagai, Yoshitaka, Tomiyama, Takami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138602/
https://www.ncbi.nlm.nih.gov/pubmed/35625816
http://dx.doi.org/10.3390/biomedicines10051080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138602/
https://www.ncbi.nlm.nih.gov/pubmed/35625816
http://dx.doi.org/10.3390/biomedicines10051080

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