Tamoxifen Ameliorates Cholestatic Liver Fibrosis in Mice: Upregulation of TGFβ and IL6 Is a Potential Protective Mechanism

The available treatments for cholestatic liver fibrosis are limited, and the disease often progresses to liver cirrhosis. Tamoxifen is a selective modulator of estrogen receptors, commonly used in breast cancer therapy. A recent in vitro study showed that tamoxifen deactivates hepatic stellate cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Šisl, Dino, Flegar, Darja, Filipović, Maša, Turčić, Petra, Planinić, Pavao, Šućur, Alan, Kovačić, Nataša, Grčević, Danka, Kelava, Tomislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138605/
https://www.ncbi.nlm.nih.gov/pubmed/35625945
http://dx.doi.org/10.3390/biomedicines10051209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138605/
https://www.ncbi.nlm.nih.gov/pubmed/35625945
http://dx.doi.org/10.3390/biomedicines10051209

Ejemplares similares