Cargando…

Tamoxifen Ameliorates Cholestatic Liver Fibrosis in Mice: Upregulation of TGFβ and IL6 Is a Potential Protective Mechanism

The available treatments for cholestatic liver fibrosis are limited, and the disease often progresses to liver cirrhosis. Tamoxifen is a selective modulator of estrogen receptors, commonly used in breast cancer therapy. A recent in vitro study showed that tamoxifen deactivates hepatic stellate cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Šisl, Dino, Flegar, Darja, Filipović, Maša, Turčić, Petra, Planinić, Pavao, Šućur, Alan, Kovačić, Nataša, Grčević, Danka, Kelava, Tomislav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138605/ https://www.ncbi.nlm.nih.gov/pubmed/35625945 http://dx.doi.org/10.3390/biomedicines10051209

Ejemplares similares

Transcriptome profiling of osteoclast subsets associated with arthritis: A pathogenic role of CCR2(hi) osteoclast progenitors
por: Filipović, Maša, et al.
Publicado: (2022)

Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions
por: Filipović, Maša, et al.
Publicado: (2022)

Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2(hi) Osteoclast Progenitors to the Affected Bone
por: Flegar, Darja, et al.
Publicado: (2021)

FasL (rs763110) gene polymorphism is not associated with susceptibility to rheumatoid arthritis in Croatian population
por: Artuković, Marinko, et al.
Publicado: (2020)

LPS‐induced inflammation desensitizes hepatocytes to Fas‐induced apoptosis through Stat3 activation—The effect can be reversed by ruxolitinib
por: Markotic, Antonio, et al.
Publicado: (2020)

Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells
por: Sucur, Alan, et al.
Publicado: (2017)

RNA sequencing data from osteochondroprogenitor populations in synovial joints of mice during murine model of rheumatoid arthritis
por: Lukač, Nina, et al.
Publicado: (2020)

NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms
por: Bainrauch, Ana, et al.
Publicado: (2021)

Importance of genetic polymorphisms in liver transplantation outcomes
por: Kelava, Tomislav, et al.
Publicado: (2020)

Reciprocal Alterations in Osteoprogenitor and Immune Cell Populations in Rheumatoid Synovia
por: Barbarić Starčević, Katarina, et al.
Publicado: (2022)

Elevated Concentrations of Soluble Fas and FasL in Multiple Sclerosis Patients with Antinuclear Antibodies
por: Sremec, Josip, et al.
Publicado: (2020)

The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair
por: Grčević, Danka, et al.
Publicado: (2018)

Osteoblastogenesis from synovial fluid-derived cells is related to the type and severity of juvenile idiopathic arthritis
por: Lazić, Elvira, et al.
Publicado: (2012)

Understanding the role of Fas-Fas ligand system in bone
por: Marusic, Ana, et al.
Publicado: (2012)

The presence of high mobility group box-1 and soluble receptor for advanced glycation end-products in juvenile idiopathic arthritis and juvenile systemic lupus erythematosus
por: Bobek, Dubravka, et al.
Publicado: (2014)

RANK/RANKL/OPG Signaling in the Brain: A Systematic Review of the Literature
por: Glasnović, Anton, et al.
Publicado: (2020)

Decreased plating efficiency, proliferation and osteogenic differentiation of synovial fluid mesenchymal progenitors as a marker of severity of juvenile idiopathic arthritis
por: Mosler, Elvira Lazic, et al.
Publicado: (2012)

Fas deficiency attenuates bone loss during antigen induced arthritis in mice
por: Mosler, Elvira Lazic, et al.
Publicado: (2012)

Osteoblast differentiation from synovial fluid cells in juvenile idiopathic arthritis (JIA)
por: Jelusic-Drazic, Marija, et al.
Publicado: (2012)

The influence of alpha-melanocortin enantiomers on acetaminophen-induced hepatis in mice
por: Turčić, Petra, et al.
Publicado: (2012)

Robert Jack and Louis Du Pasquier: Evolutionary Concepts in Immunology: 1st ed. (June 14, 2019); Springer Nature Switzerland AG; 145 pages (hardcover); ISBN 978-3-030-18666-1; ISBN 978-3-030-18667-8 (eBook), https://doi.org/10.1007/978-3-030-18667-8
por: Grčević, Danka
Publicado: (2019)

Fas receptor is required for estrogen deficiency-induced bone loss in mice
por: Kovacic, Natasa, et al.
Publicado: (2010)

Breast and gynecological cancers in Croatia, 1988-2008
por: Kelava, Iva, et al.
Publicado: (2012)

Upregulation of cadherin‐11 contributes to cholestatic liver fibrosis
por: Wu, Bo, et al.
Publicado: (2022)

Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice
por: Turčić, Petra, et al.
Publicado: (2009)

Mechanism of TGF-β1 inhibiting Kupffer cell immune responses in cholestatic cirrhosis
por: Qian, Jun, et al.
Publicado: (2020)

The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice
por: Blagaić, Vladimir, et al.
Publicado: (2010)

AFF3 upregulation mediates tamoxifen resistance in breast cancers
por: Shi, Yawei, et al.
Publicado: (2018)

Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model
por: Ceci, Ludovica, et al.
Publicado: (2022)

The Long Pentraxin PTX3 in Bone Homeostasis and Pathology
por: Parente, Raffaella, et al.
Publicado: (2019)

Proposed practical protocol for flow cytometry analysis of microglia from the healthy adult mouse brain: Systematic review and isolation methods’ evaluation
por: Srakočić, Sanja, et al.
Publicado: (2022)

Cholestatic hepatitis with intravenous ceftriaxone
por: Kaur, Inderpal, et al.
Publicado: (2011)

Azathioprine induced cholestatic hepatitis
por: Moses, Viju, et al.
Publicado: (2011)

Trifluoperazine-Induced Cholestatic Jaundice
por: Sharifi, Vandad, et al.
Publicado: (2010)

Cephalexin Induced Cholestatic Jaundice
por: Agrawal, Abhinav, et al.
Publicado: (2014)

Azithromycin-induced cholestatic hepatitis
por: Koffas, Apostolos, et al.
Publicado: (2017)

Current Therapies for Cholestatic Diseases
por: Méndez-Sánchez, Nahum, et al.
Publicado: (2023)

Inhibition of CBP/β‐catenin signaling ameliorated fibrosis in cholestatic liver disease
por: Kimura, Masamichi, et al.
Publicado: (2022)

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
por: Gui, Wenfang, et al.
Publicado: (2023)

Fibrosis in Autoimmune and Cholestatic Liver Disease
por: Penz-Österreicher, Melitta, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_r9it3gpn9q2sibuopqtjfppi87