Ha-Ras(V12)-Induced Multilayer Cellular Aggregates Is Mediated by Rac1 Activation Rather Than YAP Activation

We demonstrate that Ha-Ras(V12) overexpression induces the nuclear translocation of Hippo effector Yes-associated protein (YAP) in MDCK cells via the hippo-independent pathway at the confluent stage. Ha-Ras(V12) overexpression leads to the downregulation of Caveolin-1 (Cav1) and the disruption of ju...

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Detalles Bibliográficos
Autores principales: Wu, Li-Ying, Han, Chia-Lin, Lin, Hsi-Hui, Tang, Ming-Jer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138672/
https://www.ncbi.nlm.nih.gov/pubmed/35625714
http://dx.doi.org/10.3390/biomedicines10050977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138672/
https://www.ncbi.nlm.nih.gov/pubmed/35625714
http://dx.doi.org/10.3390/biomedicines10050977

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